![]() Spiro A, Buttriss JL (2014) Vitamin D: an overview of vitamin D status and intake in Europe. Finally, intermittent intake of calcifediol results in fairly stable serum 25OHD compared with greater fluctuations after intermittent oral cholecalciferol. A potential additional advantage of oral calcifediol is a linear dose-response curve, irrespective of baseline serum 25OHD, whereas the rise in serum 25OHD is lower after oral cholecalciferol, when baseline serum 25OHD is higher. ![]() Third, oral calcifediol has a higher rate of intestinal absorption and this may have important advantages in case of decreased intestinal absorption capacity due to a variety of diseases. Indeed, when using dosages ≤ 25 μg/day, serum 25OHD increased by 1.5 ± 0.9 nmol/l for each 1 μg cholecalciferol, whereas this was 4.8 ± 1.2 nmol/l for oral calcifediol. Based on the results of nine RCTs comparing physiologic doses of oral cholecalciferol with oral calcifediol, calcifediol was 3.2-fold more potent than oral cholecalciferol. ![]() Second, oral calcifediol is more potent than cholecalciferol, so that lower dosages are needed. First, oral calcifediol results in a more rapid increase in serum 25OHD compared to oral cholecalciferol. We reviewed all publications dealing with a comparison of oral cholecalciferol with oral calcifediol as to define the relative efficacy of both compounds for improving the vitamin D status. Oral intake of calcifediol (25OHD 3) rather than vitamin D itself should also be considered for oral supplementation. Cholecalciferol (vitamin D 3) and ergocalciferol (vitamin D 2) are the most widely used compounds and the relative use of both products depends on historical or practical reasons. Supplementation of food with vitamin D or using vitamin D supplements is the most widely used strategy to improve the vitamin status. Similarly, a better vitamin D status is essential for optimal efficacy of antiresorptive treatments. There is consensus that a good vitamin D status is necessary for bone and general health. Modest and even severe vitamin D deficiency is widely prevalent around the world. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |